Risk Assessment of "Other Substances" – L- tryptophan

Risk assessment of hazardous substances revisited

It is needless for occupational health doctors and scientists to mention about the importance of risk assessment of hazardous substances used in workplaces. Since the US Supreme Court sentenced the " benzene verdict " requiring better ground for the occupational exposure limit (OEL) for benzene in 1980, the research and scientific knowledge on risk assessment for hazardous substances have been ...

Use of NOAEL , benchmark dose , and other models for human risk assessment of hormonally active substances * , †

The benchmark dose (BMD) is the dose of a substance that is expected to result in a prespecified level of effect, the benchmark response level or BMR. It is a general approach to characterizing dose response, applicable to any toxicant and endpoint. A BMD is conceptually superior to a “no observed adverse effect level” (NOAEL) for this purpose because of being less determined by experimental de...

Risk assessment of hazardous impacts on urbanization and industrialization activities based upon toxic substances

A risk assessment study was conducted to predict the expected hazardous influence on the ecosystem resulted from urbanization and industrialization activities at Helwan area, Egypt. To achieve these goals, soils, plants and water samples were collected from Helwan area, and their total concentrations of inorganic contaminants (Cd, Cr, Co, Cu, Fe, Mn, Ni, Pb, and Zn) and organic pollutants; such...

Environmental risk assessment of pharmaceutical drug substances--conceptual considerations.

Drugs, i.e. active ingredients of human medicinal products, may be introduced into the environment after use in patients by sewage effluent pathways and consequently are detected at low concentrations in sewage effluents and in surface waters. Legal requirements in a number of geographical regions (Europe, US, and intended in Canada) demand environmental risk assessments (ERA) for new drug subs...

Follow-up to the 1993 Ecological Risk Assessment of Organotin Substances on Canada’s Domestic Substances List